Classrooms, faculty offices, and research laboratories are located in McCord Hall and Brehm Hall. These facilities include 16 core laboratories containing a full complement of essential equipment in support of microscopy,analytical and preparative chromatography, spectrophotometry, cell culture, bacteriology,radioisotope handling and counting, centrifugation and molecular biology. A large capacity indoor arena and associated animal holding and handling areas are located in BrehmHall and used extensively for teaching and outreach activities.

The Johnson Animal Research and Teaching Unit includes 16 rooms for whole animal research under controlled environments, metabolism studies, and intensive disease, nutrition, physiology, behavior and management research. Supporting facilities include a large animal surgery unit, tissue collection and preparation laboratory, general procedures laboratory, cell culture and embryo micro-manipulation laboratory, necropsy laboratory, and a feed mill capable of mixing premixes and complete feeds for dairy, beef, poultry, and swine.

Field instruction and research are conducted at 11 branch experiment stations located across the state. These include 5 beef herds with a total inventory of more than 1000 cows, 3 dairies with a total inventory of more than 500 cows, 3 farrow-to-finish swine units, a poultry unit, and a small sheep unit. The College of Veterinary Medicine's Cherokee Unit is available to support instructional activities with horses.